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The Senate on Tuesday confirmed Antony Blinken as America’s top diplomat, tasked with carrying out President Joe Biden’s commitment to reverse the Trump administration’s “America First” doctrine that weakened international alliances, AP reported. 

Senators voted 78-22 to approve Blinken, a longtime Biden confidant, as the nation’s 71st secretary of state, succeeding Mike Pompeo. The position is the most senior Cabinet position, with the secretary fourth in the line of presidential succession.

Blinken, 58, served as deputy secretary of state and deputy national security adviser during the Obama administration. He has pledged to be a leading force in the administration’s bid to reframe the U.S. relationship with the rest of the world after four years in which President Donald Trump questioned longtime alliances.

Shortly after his confirmation, Blinken took the oath of office at a private ceremony at the State Department. Blinken was sworn in by the director general of the U.S. Foreign Service in the Treaty Room on the department’s 7th floor outside the corridor known as “Mahogany Row” where his new office will be. He is expected to start work Wednesday.

“American leadership still matters,” Blinken told the Senate Foreign Relations Committee at his Jan. 19 confirmation hearing. “The reality is, the world simply does not organize itself. When we’re not engaged, when we’re not leading, then one of two things is likely to happen. Either some other country tries to take our place, but not in a way that’s likely to advance our interests and values, or maybe just as bad, no one does and then you have chaos.”

Blinken vowed that the Biden administration would approach the world with both humility and confidence, saying “we have a great deal of work to do at home to enhance our standing abroad.”